EXT Series Filter Capsules
Pharmaco Global’s EXT Series Filter Capsules are single-use depth filtration units engineered for high-solids pharmaceutical and bioprocess streams — where conventional filters blind prematurely and compromise GMP process reliability.
What differentiates the EXT Series is its dual-zone media architecture. An open upstream layer captures large particulates and high-solids loads early, while a tighter downstream layer retains finer particles and polishes the process fluid. This graduated retention approach maximises filter capacity, extends service life, and delivers predictable, reproducible filtration performance — scalable directly from laboratory development runs to full commercial pharmaceutical manufacturing without revalidation.
The filter media combines filter aid, cellulose, and a proprietary polymer matrix within a capsule geometry specifically designed for depth filtration. Filtration parameters established at lab scale translate reliably to production scale — reducing regulatory submission burden and tech transfer timelines under WHO GMP, USFDA, and EU GMP frameworks.
Each EXT Series capsule is engineered to minimise product loss through low hold-up volume and tool-free, sanitary connections that simplify installation across sterile and non-sterile manufacturing lines. The single-use format eliminates cleaning validation requirements, removes batch-to-batch cross-contamination risk, and streamlines GMP documentation — making it a practical choice for pharmaceutical, biopharmaceutical, and bioprocessing facilities operating under tightly controlled quality systems.
Related products
Frequently Asked Questions
EXT Series filter capsules are single-use, dual-layer depth filter capsules designed for economical small-scale clarification of pharmaceutical, biopharmaceutical, vaccine, and biological fluids. Their extended dual-layer media structure delivers higher throughput and improved filtrate clarity compared to single-layer depth filter formats — ideal for process development and scale-up studies.
The EXT Series dual-layer design has an open upstream zone that captures large particles and reduces gross turbidity, and a tighter downstream zone that removes finer sub-micron contaminants via mechanical retention and charge-based adsorption. This gradient structure maximises dirt-holding capacity, extends filter service life, and delivers clearer filtrate throughput.
EXT Series capsules use depth filtration media composed of inorganic filter aid (diatomite), cellulose fibres, and a positively charged resin system. The charged resin electrokinetically captures negatively charged sub-micron particles and soluble contaminants — removing impurities that mechanical sieving alone cannot retain from complex biological process fluids.
EXT Series capsules are available in 25 cm² for laboratory screening, 170 cm² and 340 cm² for scale-up studies, and 1020 cm² for small-volume production filtration. The identical lenticular design and media chemistry across all sizes enables direct, linear scale-up by surface area — with no need to revalidate media performance between scales.
EXT Series capsules are used for harvest clarification of cell culture and fermentation broths, pre-filtration of biological bulk solutions before membrane filtration, vaccine intermediate clarification, blood fractionation, and API solution prefiltration — especially where high particulate loads would rapidly foul downstream 0.22 µm sterilising-grade filters without upstream depth prefiltration.
EXT Series capsules provide higher dirt-holding capacity and longer operational life than single-layer depth capsules, due to their extended gradient media. They maintain the same single-use closed-system benefits and FDA DMF support — making them the preferred choice when standard single-layer formats exhaust prematurely during challenging, high-turbidity pharmaceutical processing runs.
Yes. EXT Series filter capsules are manufactured per controls documented in an FDA Drug Master File (DMF). They comply with USP <88> Class VI Biological Reactivity Tests for biocompatibility. A lot-specific Certificate of Quality (CoQ) is included with every unit, supporting pharmaceutical GMP batch records and regulatory submission documentation.
Throughput depends on the fluid's particulate load, viscosity, and selected media grade. The 25 cm² capsule suits volumes under 1 L for media screening; the 1020 cm² capsule handles multi-litre pilot batches. Conducting a small-scale filterability study using actual process fluid is recommended before predicting full-scale production throughput requirements.
Yes, all our products are designed and sourced to meet international regulatory standards, including GMP, USFDA, EU-GMP, WHO, and other relevant compliance requirements.
Absolutely. Our solutions are engineered for seamless integration with existing systems, ensuring minimal disruption and optimal performance within your current setup.
Yes, our team offers technical consultation to help you choose the most suitable product based on your process requirements, facility design, and compliance needs.
Yes, all our products are aligned with our turnkey execution approach, ensuring compatibility with overall facility design, engineering, and operational requirements.
Yes, we provide customised solutions tailored to your process, capacity, and regulatory requirements to ensure optimal performance and efficiency.
Our products are used across pharmaceutical manufacturing, biotechnology, nutraceuticals, research laboratories, and regulated healthcare environments.
We follow strict quality standards and work with trusted technologies and manufacturing processes to ensure consistent performance, durability, and compliance.
Yes, we offer ongoing technical support to ensure smooth operation, performance optimisation, and long-term reliability of all supplied systems and components.
