Holders
Pharmaco Global’s filter holders for pharmaceutical filtration are mechanical housing units designed to secure, seal, and support filtration membranes and cassettes during pharmaceutical and bioprocess filtration operations. They provide the structural framework, controlled flow path, and port connectivity required to operate filtration media consistently and safely across laboratory, pilot, and commercial manufacturing scales.
The range covers both capsule filter holders and flat-sheet cassette configurations, with manual and hydraulic clamping variants available to suit differing operational scales and throughput requirements. Manual holders offer the flexibility needed during process development and smaller-scale applications, whilst hydraulic holders deliver the consistent clamping force required to maintain seal integrity across multi-cassette assemblies in production.
These pharmaceutical filtration holder systems are engineered to ensure leak-proof sealing, uniform flow distribution, and compatibility with validated filtration processes, supporting GMP-compliant manufacturing and reliable process performance.
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Frequently Asked Questions
Pharmaceutical filter holders are reusable devices that secure and support flat membrane disc filters during laboratory filtration. They are used for sterility testing, bioburden analysis, water quality testing, HPLC sample preparation, and analytical filtration — enabling reproducible, controlled filtration of small to medium liquid volumes through validated pharmacopoeial membrane discs.
Pharmaceutical labs use syringe-type inline holders (13 mm, 25 mm) for small-volume sample preparation; vacuum disc holders (47 mm, 90 mm, 142 mm) for gravity or vacuum filtration; SS316L pressure holders for viscous or larger-volume applications; and autoclavable glass or polysulfone holders for sterility and microbiological membrane filtration workflows.
Pharmaceutical filter holders are made from SS316L stainless steel (preferred for GMP — autoclavable, electropolished, corrosion-resistant), borosilicate glass (chemically inert, transparent), polypropylene (lightweight, cost-effective for general lab use), and polycarbonate — all incorporating PTFE or silicone gaskets and O-rings for chemical compatibility and leak-free sealing during filtration.
Filter holders are designed for standard membrane disc diameters: 13 mm and 25 mm for syringe-type inline holders; 47 mm for standard vacuum and pressure disc holders; 90 mm and 142 mm for larger laboratory filtration volumes. The holder diameter must exactly match the membrane disc size to prevent bypass around the filter edge.
SS316L stainless steel filter holders are sterilised by autoclaving at 121°C for 15–20 minutes with the membrane disc assembled in place. After sterilisation, holders are used immediately in a laminar airflow unit or biosafety cabinet. Some GMP-grade stainless steel holders also support steam-in-place (SIP) sterilisation for cleanroom-integrated filtration workflows.
Vacuum holders draw liquid through the membrane using negative pressure below the filter — suited for aqueous samples and standard microbiological membrane filtration. Pressure holders push liquid through using positive pressure above the filter — better suited for viscous solutions, organic solvents, or larger volumes where vacuum may degas or disrupt the sample.
Select based on: volume (13/25 mm for <50 mL; 47 mm for 50–500 mL; 90/142 mm for >500 mL); operating mode (vacuum vs. pressure); material (SS316L for GMP environments; polypropylene for general lab); and required membrane disc diameter matching the validated pharmacopoeial or analytical method being performed.
Reusable SS316L filter holders must have validated cleaning and sterilisation procedures between uses. Cleaning validation must confirm removal of previous sample residues. Holders require periodic inspection for gasket and seal integrity. Equipment logbooks, sterilisation cycle records, and maintenance schedules must be maintained as GMP records per 21 CFR Part 211 and EU GMP Chapter 6.
Yes, all our products are designed and sourced to meet international regulatory standards, including GMP, USFDA, EU-GMP, WHO, and other relevant compliance requirements.
Absolutely. Our solutions are engineered for seamless integration with existing systems, ensuring minimal disruption and optimal performance within your current setup.
Yes, our team offers technical consultation to help you choose the most suitable product based on your process requirements, facility design, and compliance needs.
Yes, all our products are aligned with our turnkey execution approach, ensuring compatibility with overall facility design, engineering, and operational requirements.
Yes, we provide customised solutions tailored to your process, capacity, and regulatory requirements to ensure optimal performance and efficiency.
Our products are used across pharmaceutical manufacturing, biotechnology, nutraceuticals, research laboratories, and regulated healthcare environments.
We follow strict quality standards and work with trusted technologies and manufacturing processes to ensure consistent performance, durability, and compliance.
Yes, we offer ongoing technical support to ensure smooth operation, performance optimisation, and long-term reliability of all supplied systems and components.
