Zeta Plus Encapsulated Filters
Pharmaco Global’s Zeta Plus encapsulated filters for pharmaceutical filtration are advanced depth filtration units designed to remove sub-micron and charged contaminants that conventional filters cannot capture.
Many contaminants in pharmaceutical and bioprocess manufacturing are too fine or carry an electrical charge, allowing them to pass through standard depth filters. These filters address this through a combination of mechanical retention and electrokinetic adsorption.
Key Features
- Removes fine and charged particles
- Consistent filtration performance
- Encapsulated design for safe handling
- Suitable for critical filtration applications
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Frequently Asked Questions
Zeta Plus encapsulated filters are single-use, closed-system depth filtration capsules used for clarification, prefiltration, and bioburden reduction in pharmaceutical and biopharmaceutical manufacturing. They combine mechanical particle retention with electrokinetic (charge-based) adsorption — removing sub-micron particles, colloids, and negatively charged contaminants from complex biological and chemical process fluids.
Zeta Plus media combines cellulose fibres, inorganic filter aid (diatomite), and a positively charged resin system. The charged surface electrokinetically attracts and retains negatively charged sub-micron particles and soluble contaminants — capturing impurities too small for mechanical sieving alone, significantly improving filtrate clarity and protecting downstream sterilising-grade membrane filters.
Zeta Plus encapsulated filters are used for biopharmaceutical harvest clarification (cell culture and fermentation broths), vaccine intermediate clarification, blood fractionation, small molecule API solution clarification, and as prefiltration ahead of sterilising-grade membrane filters — preventing premature plugging of 0.22 µm sterilising filters by high-particulate upstream process fluids.
Zeta Plus SP Series capsules use two distinct media zones: an open upstream layer capturing large particles and reducing gross turbidity, and a tighter downstream layer removing finer particles via mechanical and charge-based retention. This gradient structure maximises dirt-holding capacity and throughput — outperforming single-layer depth filter formats in challenging biological process streams.
The Zeta Plus encapsulated system is available in BC25 (25 cm², lab screening), 170 cm² and 340 cm² (scale-up studies), and 1020 cm² (small production batches) — processing from 0.5 L to 2,500+ L per campaign. Identical lenticular design across all sizes enables direct, linear scale-up by surface area without revalidating media performance.
Yes. Zeta Plus encapsulated filters are manufactured under controls documented in an FDA Drug Master File (DMF). They comply with USP <88> Class VI Biological Reactivity Tests. A lot-specific Certificate of Quality (CoQ) accompanies every unit — providing the GMP batch documentation required for pharmaceutical regulatory submissions to FDA, EMA, and other global health authorities.
Zeta Plus BC Series capsules use a single-layer depth media for standard clarification with moderate particulate loads — cost-effective for general pharmaceutical prefiltration. SP Series capsules use a dual-layer graded media structure providing significantly higher dirt-holding capacity and superior clarification — the preferred choice for challenging, high-turbidity biopharmaceutical harvest and clarification workflows.
Comprehensive extractables and leachables (E&L) data packages are available from the manufacturer, generated per BPOG extraction protocols under standard pharmaceutical conditions. These packages support ICH Q3D elemental impurity assessments and drug product compatibility studies — required for pharmaceutical regulatory submissions to FDA, EMA, PMDA, and Health Canada for biological and small molecule drug products.
Yes, all our products are designed and sourced to meet international regulatory standards, including GMP, USFDA, EU-GMP, WHO, and other relevant compliance requirements.
Absolutely. Our solutions are engineered for seamless integration with existing systems, ensuring minimal disruption and optimal performance within your current setup.
Yes, our team offers technical consultation to help you choose the most suitable product based on your process requirements, facility design, and compliance needs.
Yes, all our products are aligned with our turnkey execution approach, ensuring compatibility with overall facility design, engineering, and operational requirements.
Yes, we provide customised solutions tailored to your process, capacity, and regulatory requirements to ensure optimal performance and efficiency.
Our products are used across pharmaceutical manufacturing, biotechnology, nutraceuticals, research laboratories, and regulated healthcare environments.
We follow strict quality standards and work with trusted technologies and manufacturing processes to ensure consistent performance, durability, and compliance.
Yes, we offer ongoing technical support to ensure smooth operation, performance optimisation, and long-term reliability of all supplied systems and components.
